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Melatonin restores microglial function, reduces plaques, and improves cognitive scores (Table 3, Supplementary Materials Table S4) [110]

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And I think that point has to do with the intermittent challenging of yourself and whether that is through temperature changes, like cold or heat, or through other types of stressors, like physical activity or perhaps even dietary compounds that are found in plants, these are things like polyphenols or flavanols