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The functions of amylin are complementary to insulin and to GLP-1 : Slows gastric emptying , similarly to GLP-1, but more strongly Suppresses glucagon , helps control postprandial glycemia Induces satiety , via the area postrema in the brainstem Regulates weight balance , long-term effect In type 2 diabetes amylin secretion deteriorates in parallel with insulin secretion , as the disease progresses, the β-cells lose the ability to produce both hormones at once
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In addition, while a direct leucine infusion into normally grown late-gestation fetal sheep potentiated insulin secretion and resulted in increased β-cell proliferation, β-cell mass, islet size, and pancreatic insulin content (36), these findings were absent in FGR fetal sheep and their islets in response to a fetal leucine infusion (36, 49)