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Cell and animal model results found that Hcy upregulates ER oxidoreductin-1α (Ero-1α) expression by promoting binding of hypoxia-inducible factor-1α (HIF-1α) to the Ero-1α promoter and downregulates the antioxidant pathway mediated by ER glutathione peroxidase (GPX) 7 to induce ERS and disrupt ER homeostasis (89)

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Similarly, for rosacea, Glutathione can help to reduce inflammation and the appearance of redness and irritation