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doi: 10.1089/ars.2017.7382 73 FedorovaMBollineniRCHoffmannR

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In this study, glutamine flux was directed toward the generation of R-2-HG in IDH1/2 mutant cells, and the kinetics of R-2-HG formation were proportionally of the same order of magnitude as those of glutamate or α-KG formation via glutaminolysis